Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8340296 | 0.94 | TACR1 (0.35) | GAAUSP2DRD2DRD4DRD3 | |
| SCHEMBL8340133 | 0.89 | TDP1 (0.37) | GAAALDH1A1SMN1; SMN2RAB9ALMNA | |
| SCHEMBL8336415 | 0.77 | SMN1; SMN2 (0.33) | GAADRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL8335504 | 0.67 | TDP1 (0.35) | GAADRD2DRD3ALDH1A1SMN1; SMN2 | |
| SCHEMBL8339395 | 0.66 | TSHR (0.31) | GAAALDH1A1RAB9AL3MBTL1KMT2A | |
| SCHEMBL8335763 | 0.65 | TSHR (0.35) | ALDH1A1 | |
| SCHEMBL14873200 | 0.61 | LMNA (0.57) | GAAALDH1A1SMN1; SMN2RAB9ALMNA | |
| SCHEMBL8339931 | 0.61 | TDP1 (0.48) | ALDH1A1SMN1; SMN2RAB9ALMNAKMT2A | |
| SCHEMBL8337202 | 0.60 | HPGD (0.39) | GAAALDH1A1SMN1; SMN2RAB9ALMNA | |
| SCHEMBL8335612 | 0.60 | LMNA (0.40) | GAAALDH1A1SMN1; SMN2RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |