Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8178691 | 0.86 | MAPT (0.40) | MEN1KMT2APOLBKDM4ENPC1 | |
| SCHEMBL5120176 | 0.84 | MAPT (0.40) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8338912 | 0.82 | RXRA (0.41) | MEN1KMT2APOLBTDP1KDM4E | |
| SCHEMBL8334672 | 0.80 | RARA (0.41) | MEN1KMT2APOLBTDP1KDM4E | |
| SCHEMBL8179818 | 0.78 | FYN (0.44) | MEN1KMT2APOLBCTDSP1KDM4E | |
| SCHEMBL5119695 | 0.77 | CYP2A6 (0.50) | KMT2APOLBKDM4ENPC1RAB9A | |
| SCHEMBL8335829 | 0.77 | RXRA (0.40) | MEN1KMT2APOLBTDP1KDM4E | |
| SCHEMBL8338691 | 0.77 | SELE (0.45) | MEN1KMT2AKDM4EALDH1A1RXRA | |
| SCHEMBL8185712 | 0.76 | PDE5A (0.47) | MEN1KMT2APOLBCTDSP1KDM4E | |
| SCHEMBL8340672 | 0.75 | BRD4 (0.46) | NPC1RAB9ASMN1; SMN2HPGDRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948911-A | Method for inhibiting neoplastic cells and related conditions by exposure to thienopyrimidine derivatives | CELL PATHWAYS, INC. (US) | 1999-09-07 | — | — | US | disclosed |