Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3150694 | 0.82 | LMNA (0.50) | LMNACYP3A4TRPM8ALDH1A1TP53 | |
| SCHEMBL11402402 | 0.82 | TRPM8 (0.49) | LMNACYP3A4TRPM8ALDH1A1TP53 | |
| SCHEMBL1954826 | 0.79 | SIGMAR1 (0.44) | SIGMAR1LMNACYP3A4TRPM8ALDH1A1 | |
| SCHEMBL5032969 | 0.78 | LMNA (0.44) | SIGMAR1LMNACYP3A4TRPM8ALDH1A1 | |
| SCHEMBL29624292 | 0.78 | SIGMAR1 (0.43) | SIGMAR1LMNACYP3A4TRPM8ALDH1A1 | |
| SCHEMBL27750410 | 0.77 | LMNA (0.41) | LMNACYP3A4TRPM8ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL27750411 | 0.76 | SIGMAR1 (0.54) | SIGMAR1LMNACYP3A4ALDH1A1HSD17B1 | |
| SCHEMBL4919799 | 0.76 | SIGMAR1 (0.42) | SIGMAR1LMNACYP3A4TRPM8ALDH1A1 | |
| SCHEMBL8155203 | 0.74 | SIGMAR1 (0.45) | SIGMAR1LMNACYP3A4TRPM8ALDH1A1 | |
| SCHEMBL27455559 | 0.74 | SIGMAR1 (0.38) | SIGMAR1LMNACYP3A4TRPM8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999007377-A1 | 1-[4-(SUBSTITUTED ALKOXY)BENZYL]NAPHTHALENE COMPOUNDS HAVING ESTROGEN INHIBITORY ACTIVITY | ELI LILLY AND COMPANY (US) | 1999-02-18 | — | — | WO | disclosed |