Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686484 | 0.82 | SIGMAR1 (0.32) | SIGMAR1LMNACYP3A4TRPM8POLB | |
| SCHEMBL1954826 | 0.79 | SIGMAR1 (0.44) | SIGMAR1LMNACYP3A4TRPM8POLB | |
| SCHEMBL1116324 | 0.78 | KDM4E (0.43) | LMNACYP3A4POLBALDH1A1TP53 | |
| SCHEMBL29624292 | 0.78 | SIGMAR1 (0.43) | SIGMAR1LMNACYP3A4TRPM8POLB | |
| SCHEMBL11174076 | 0.78 | MYC (0.36) | CYP3A4POLBALDH1A1TP53KDM4E | |
| SCHEMBL1116304 | 0.78 | CYP3A4 (0.36) | CYP3A4POLBALDH1A1TP53TSHR | |
| SCHEMBL11541431 | 0.77 | TP53 (0.39) | LMNACYP3A4TRPM8ALDH1A1TP53 | |
| SCHEMBL11543026 | 0.77 | GABRA1 (0.38) | SIGMAR1LMNAALDH1A1TP53TSHR | |
| SCHEMBL4199227 | 0.77 | TDP1 (0.38) | ALDH1A1TP53KDM4EGAAMAPT | |
| SCHEMBL14053250 | 0.76 | CES2 (0.39) | ALDH1A1GAASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0554275-B1 | ACID BATH FOR COPPER PLATING, AND A PROCESS USING A BATH OF THIS TYPE FOR THIS PURPOSE | ATOTECH DEUTSCHLAND GMBH (DE) | 1994-12-14 | — | — | EP | claimed |
| EP-0013007-B1 | PROCESS FOR THE PREPARATION OF 4-METHYL-2-AMINO-BENZOTHIAZOLE | LONZA AG (CH) | 1982-02-10 | — | — | EP | claimed |
| CN-102325801-B | Curable composition, cured product thereof, and method for producing same | KANEKA CORP | 2015-02-25 | — | — | CN | disclosed |
| CN-102325801-A | Curable composition, cured product thereof, and method for producing same | KANEKA CORP | 2012-01-18 | — | — | CN | disclosed |
| US-20080125432-A1 | 5-Carboxamido Substituted Thiazole Derivatives that Interact With Ion Channels, In Particular With Ion Channels From the Kv Family | DEVGEN NV (BE) | 2008-05-29 | — | — | US | disclosed |
| CN-101098698-A | 5-carboxamido-substituted thiazole derivatives which interact with ion channels, in particular ion channels of the Kv family | DEVGEN NV (BE) | 2008-01-02 | — | — | CN | disclosed |
| EP-1819330-A1 | 5-CARBOXAMIDO SUBSTITUED THIAZOLE DERIVATIVES THAT INTERACT WITH ION CHANNELS, IN PARTICULAR WITH ION CHANNELS FROM THE KV FAMILY | Devgen N.V. (BE) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006058905-A1 | 5-CARBOXAMIDO SUBSTITUTED THIAZOLE DERIVATIVES THAT INTERACT WITH ION CHANNELS, IN PARTICULAR WITH ION CHANNELS FROM THE Kv FAMILY | DEVGEN NV (BE) | 2006-06-08 | — | — | WO | disclosed |
| US-20040116490-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2004-06-17 | — | — | US | disclosed |
| EP-1381360-A1 | COMPOUNDS AND METHODS FOR INHIBITING METAP2 IN MAMMALS | SmithKline Beecham Corporation (US) | 2004-01-21 | — | — | EP | disclosed |
| WO-2002078697-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | disclosed |
| US-4148799-A | Process for the preparation of 2-aryliminothiazoline solutions | BAYER AKTIENGESELLSCHAFT (DE) | 1979-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125432-A1 | 5-Carboxamido Substituted Thiazole Derivatives that Interact With Ion Channels, In Particular With Ion Channels From the Kv Family | KCNA5, KCNA1, KCNJ2 | SIGMAR1 1277/4885LMNA 2199/4885CYP3A4 465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.