Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | BCKDK | O14874 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | IGFBP5 | P24593 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5410407 | 0.98 | DHODH (0.42) | DHODHKMOKMT2ADYRK1ABCKDK | |
| SCHEMBL9441972 | 0.89 | ALDH1A1 (0.48) | DHODHPOLBPTGESALDH1A1ALOX5 | |
| 7-Chlorokynurenic Acid SCHEMBL157187 | 0.82 | IGFBP3 (0.47) | DHODHKMOKMT2ADYRK1APOLB | |
| 7-Chlorokynurenic Acid SCHEMBL31238955 | 0.82 | IGFBP3 (0.47) | DHODHKMOKMT2ADYRK1APOLB | |
| SCHEMBL15129999 | 0.82 | ALDH1A1 (0.51) | DHODHKMOKMT2APOLBPTGES | |
| 7-Chlorokynurenic Acid SCHEMBL29386783 | 0.82 | IGFBP3 (0.47) | DHODHKMOKMT2ADYRK1APOLB | |
| SCHEMBL9441975 | 0.81 | ALOX15 (0.39) | DHODHKMOBCKDKALDH1A1HIF1A | |
| SCHEMBL9441961 | 0.81 | MCL1 (0.43) | KMT2AMCL1RXFP1ALDH1A1IGFBP3 | |
| 7-Chlorokynurenic Acid SCHEMBL20770380 | 0.81 | IGFBP3 (0.46) | DHODHKMOKMT2ADYRK1APOLB | |
| SCHEMBL14578175 | 0.80 | ALOX15 (0.58) | DHODHKMT2APOLBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170072005-A1 | COMBINATIONS OF NMDAR MODULATING COMPOUNDS | UNIV NORTHWESTERN (US) | 2017-03-16 | — | — | US | disclosed |
| US-20170072005-A1 | COMBINATIONS OF NMDAR MODULATING COMPOUNDS | UNIV NORTHWESTERN (US) | 2017-03-16 | — | — | US | disclosed |
| WO-2004039371-A2 | COMPOSITIONS OF CYCLOOXYGENASE-2 SELECTIVE INHIBITORS AND NMDA RECEPTOR ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF NEUROPATHIC PAIN | PHARMACIA CORPORATION (US) | 2004-05-13 | — | — | WO | disclosed |
| US-5250541-A | Neurological disorders | FIDIA S.P.A. (IT) | 1993-10-05 | — | — | US | disclosed |
| WO-1991001973-A1 | KYNURENIC ACID DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FIDIA S.P.A. (IT) | 1991-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170072005-A1 | COMBINATIONS OF NMDAR MODULATING COMPOUNDS | GRIN1, GRIN2A, GRIN3A | DHODH 4325/4885KMO 555/4885KMT2A 1130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.