Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | MC3R | P41968 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20379780 | 0.76 | CA2 (0.33) | — | |
| SCHEMBL20379773 | 0.72 | MMP1 (0.33) | KDM4EKMT2AMEN1LMNA | |
| SCHEMBL22095449 | 0.70 | HPGD (0.41) | KMT2ANPC1RAB9ASMN1; SMN2MEN1 | |
| Phosphoric Acid SCHEMBL28401191 | 0.70 | NPC1 (0.40) | KDM4ENAPRTHCAR2ADORA3TSHR | |
| Phosphoric Acid SCHEMBL11735615 | 0.70 | HSP90AA1 (0.41) | KDM4ENAPRTHCAR2ADORA3TSHR | |
| SCHEMBL22990157 | 0.69 | CA1 (0.45) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22990166 | 0.69 | CA1 (0.45) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11130298 | 0.67 | KMT2A (0.46) | KDM4ENAPRTHCAR2TSHRKMT2A | |
| SCHEMBL10646272 | 0.67 | PGK1 (0.45) | KDM4ENAPRTHCAR2FDPS | |
| SCHEMBL16166717 | 0.67 | KDM4E (0.40) | KDM4ENAPRTHCAR2ADORA3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1063180-C | 5H, 10H-imidazo [1, 2 -a] indeno [1, 2 -e] pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives | RHONE POULENC RORER SA (FR) | 2001-03-14 | — | — | CN | claimed |
| CN-1180357-A | 5H, 10H-imidazo [1, 2-a ] indeno [1, 2-e ] pyrazin-4-one derivatives, preparation thereof and medicaments containing same | RHONE POULENC RORER SA (FR) | 1998-04-29 | — | — | CN | claimed |
| CN-105085418-B | A kind of diphenyl replaces the synthetic method of pyrazine compounds | 江俞 | 2017-08-04 | — | — | CN | disclosed |
| CN-105085419-B | A kind of synthetic method of pyrazine compounds | 郑华杨 | 2017-06-23 | — | — | CN | disclosed |
| CN-1063180-C | 5H, 10H-imidazo [1, 2 -a] indeno [1, 2 -e] pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives | RHONE POULENC RORER SA (FR) | 2001-03-14 | — | — | CN | disclosed |
| US-5902803-A | 5H,10H-imidazo 1,2-a!indeno 1,2-e!pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives | RHONE-POULENC RORER S.A. (FR) | 1999-05-11 | — | — | US | disclosed |
| CN-1207102-A | 5h,10h-imidazo[1,2-alpha] indeno [1,2-3] pyrazine-4-one derivatives preparation thereof, intermediates thereof and drugs containing same | RHONE POULENC RORER SA (FR) | 1999-02-03 | — | — | CN | disclosed |
| CN-1180357-A | 5H, 10H-imidazo [1, 2-a ] indeno [1, 2-e ] pyrazin-4-one derivatives, preparation thereof and medicaments containing same | RHONE POULENC RORER SA (FR) | 1998-04-29 | — | — | CN | disclosed |