Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.41 |
| ▸ | MMP2 | P08253 | 5/20 | 0.39 |
| ▸ | MMP9 | P14780 | 4/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | ACP3 | P15309 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6841039 | 0.87 | MMP2 (0.38) | ADAMTS5MMP2MMP9MMP8MMP3 | |
| SCHEMBL6839920 | 0.85 | MMP2 (0.36) | ADAMTS5MMP2MMP9MMP8FFAR1 | |
| SCHEMBL6842461 | 0.84 | MMP2 (0.40) | ADAMTS5MMP2MMP9MMP8FFAR1 | |
| SCHEMBL6799515 | 0.80 | MMP2 (0.39) | ADAMTS5MMP2MMP9MMP8FFAR1 | |
| SCHEMBL6791637 | 0.77 | ADAM17 (0.50) | ADAMTS5MMP2MMP9MMP8CYP1A2 | |
| SCHEMBL6787210 | 0.77 | CYP3A4 (0.39) | MMP2MMP9MMP8LMNACYP1A2 | |
| SCHEMBL6791760 | 0.77 | MMP2 (0.34) | ADAMTS5MMP2MMP9MMP8MMP3 | |
| SCHEMBL11933939 | 0.75 | ADAM17 (0.48) | ADAMTS5MMP2MMP9MMP8RAB9A | |
| SCHEMBL6791581 | 0.74 | MMP13 (0.36) | ADAMTS5MMP2MMP9FFAR1MMP13 | |
| SCHEMBL6786868 | 0.72 | HSD11B1 (0.33) | ADAMTS5MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024060-A2 | METALLOPROTEINASE INHIBITORS AND INTERMEDIATES FOR PREPARATION THEREOF | ASTRAZENECA AB (SE) | 2004-03-25 | — | — | WO | disclosed |