Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.38 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 6/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9868786 | 0.86 | TSHR (0.39) | PARP1IKBKBCHUKJAK2JAK1 | |
| SCHEMBL9869743 | 0.84 | KDM4E (0.50) | PARP1IKBKBJAK2NPC1RAB9A | |
| SCHEMBL9478335 | 0.78 | RXRA (0.46) | NPC1RAB9AATMKMT2ANUDT1 | |
| SCHEMBL8337977 | 0.69 | TLR8 (0.50) | PARP1TLR8JAK2JAK1TYK2 | |
| SCHEMBL2834342 | 0.66 | RIPK2 (0.70) | HTTPARP1NPC1RAB9AATM | |
| SCHEMBL8335601 | 0.65 | RIPK2 (0.46) | JAK2JAK1TYK2JAK3NPC1 | |
| SCHEMBL8339312 | 0.65 | CDC7 (0.43) | JAK2JAK1TYK2JAK3KCNH2 | |
| SCHEMBL30927156 | 0.64 | MKNK1 (0.60) | PARP1IKBKBCHUKJAK2NPC1 | |
| SCHEMBL15428638 | 0.63 | DCAF1 (0.54) | PARP1IKBKBCHUKJAK2JAK1 | |
| SCHEMBL27922044 | 0.62 | PARP1 (0.55) | PARP1IKBKBCHUKJAK2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5013737-A | Hypotensive, anxiolytic, cognitive disorders | AMERICAN CYANAMID COMPANY (US) | 1991-05-07 | — | — | US | disclosed |