Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8339477 | 0.89 | GPR88 (0.40) | GPR88HDAC1HDAC7CYP1A2CYP3A4 | |
| SCHEMBL8339028 | 0.88 | GAA (0.33) | TDP1KDM4ELMNACNR2CNR1 | |
| SCHEMBL8337813 | 0.83 | TDP1 (0.39) | TDP1GPR88HDAC1HDAC7CYP1A2 | |
| SCHEMBL8336209 | 0.81 | GPR88 (0.35) | TDP1GPR88HDAC1HDAC7MMP1 | |
| SCHEMBL8341296 | 0.81 | TDP1 (0.40) | TDP1CYP1A2CYP3A4CYP2C9PKM | |
| SCHEMBL8338140 | 0.81 | MMP9 (0.38) | TDP1CYP1A2CYP3A4CYP2C9PKM | |
| SCHEMBL8338089 | 0.80 | TDP1 (0.37) | TDP1GPR88CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8338207 | 0.80 | TDP1 (0.37) | TDP1HDAC1HDAC7CYP1A2CYP3A4 | |
| SCHEMBL8334670 | 0.80 | MMP9 (0.41) | TDP1HDAC1HDAC7CYP1A2CYP3A4 | |
| SCHEMBL8340209 | 0.79 | ADAM17 (0.36) | TDP1GPR88HDAC1HDAC7HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |