Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 3/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8338348 | 0.89 | TDP1 (0.39) | GPR88HDAC1HDAC7CYP1A2CYP3A4 | |
| SCHEMBL8341137 | 0.82 | CYP1A2 (0.38) | GPR88HDAC1HDAC7CYP1A2CYP3A4 | |
| SCHEMBL8336514 | 0.80 | PKM (0.37) | GPR88HDAC1HDAC7CYP1A2CYP3A4 | |
| SCHEMBL8389782 | 0.80 | GPR88 (0.36) | GPR88HDAC1HDAC7CNR2MEN1 | |
| SCHEMBL8340431 | 0.80 | MMP9 (0.39) | HDAC1HDAC7CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8338276 | 0.79 | TAS1R3 (0.37) | GPR88HDAC1HDAC7CYP1A2CYP3A4 | |
| SCHEMBL8337089 | 0.79 | MMP9 (0.43) | HDAC1HDAC7CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8337030 | 0.78 | MMP1 (0.35) | GPR88HDAC1HDAC7CNR2CNR1 | |
| SCHEMBL8336209 | 0.78 | GPR88 (0.35) | GPR88HDAC1HDAC7CNR2MMP1 | |
| SCHEMBL8336849 | 0.78 | MMP9 (0.44) | HDAC1HDAC7CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |