Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.58 |
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | ADH5 | P11766 | 4/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22641616 | 0.86 | NOTUM (0.58) | NOTUMIDO1ADH5CYP19A1CYP11B1 | |
| SCHEMBL12117429 | 0.84 | CYP11B1 (0.56) | NOTUMIDO1ADH5CYP19A1CYP11B1 | |
| SCHEMBL10800440 | 0.84 | NOTUM (0.63) | NOTUMIDO1ADH5CYP19A1CYP11B1 | |
| SCHEMBL28366763 | 0.79 | ENPP2 (0.58) | NOTUMIDO1ADH5CYP19A1CYP11B1 | |
| SCHEMBL993223 | 0.79 | LMNA (0.58) | NOTUMIDO1ADH5CYP19A1CYP11B1 | |
| SCHEMBL10053600 | 0.78 | L3MBTL1 (0.49) | CYP19A1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL8337178 | 0.77 | CYP11B1 (0.53) | NOTUMIDO1ADH5CYP19A1CYP11B1 | |
| SCHEMBL18101813 | 0.77 | CYP11B1 (0.59) | NOTUMIDO1ADH5CYP19A1CYP11B1 | |
| SCHEMBL22393891 | 0.76 | ENPP2 (0.58) | NOTUMIDO1ADH5CYP19A1CYP11B1 | |
| SCHEMBL15889916 | 0.76 | CYP19A1 (0.51) | NOTUMIDO1ADH5CYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| CN-101798298-B | Imidazole derivatives | HOFFMANN LA ROCHE | 2013-01-09 | — | — | CN | disclosed |
| CN-101798298-A | Imdazole derivatives | HOFFMANN LA ROCHE | 2010-08-11 | — | — | CN | disclosed |
| CN-1489580-B | Imidazole derivatives | HOFFMANN LA ROCHE | 2010-05-26 | — | — | CN | disclosed |
| CN-1489580-A | Imidazole derivatives | - | 2004-04-14 | — | — | CN | disclosed |