Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.52 |
| ▸ | FEN1 | P39748 | 2/20 | 0.52 |
| ▸ | TOP2A | P11388 | 1/20 | 0.49 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8341968 | 0.88 | NPC1 (0.51) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8339223 | 0.86 | MAPT (0.51) | ALDH1A1ERCC5FEN1MAPTNPSR1 | |
| SCHEMBL8338985 | 0.84 | ESR2 (0.56) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8340977 | 0.81 | NPC1 (0.54) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8335416 | 0.80 | KDM4E (0.47) | ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL8341523 | 0.80 | L3MBTL1 (0.49) | ALDH1A1ERCC5FEN1MAPTSMN1; SMN2 | |
| SCHEMBL10583830 | 0.79 | ALDH1A1 (0.64) | ALDH1A1ERCC5FEN1MMP1MAPT | |
| SCHEMBL8738919 | 0.79 | ALDH1A1 (0.64) | ALDH1A1ERCC5FEN1MMP1SMN1; SMN2 | |
| SCHEMBL8136965 | 0.77 | ERCC5 (0.58) | ALDH1A1ERCC5FEN1MMP1HPGD | |
| SCHEMBL28441720 | 0.76 | ERCC5 (0.60) | ALDH1A1ERCC5FEN1MMP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5968975-A | TREATING ATHEROSCLEROSIS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1998057925-A1 | ELEVATION OF HDL CHOLESTEROL BY 2-[(AMINOTHIOXOMETHYL)-HYDRAZONO]-2-ARYLETHYL CARBAMATES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |