Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8339223 | 0.91 | MAPT (0.51) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL8338779 | 0.88 | ALDH1A1 (0.64) | NPC1RAB9AALDH1A1HPGDMAPT | |
| SCHEMBL8340977 | 0.85 | NPC1 (0.54) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL8335416 | 0.84 | KDM4E (0.47) | NPC1RAB9AKMT2AALDH1A1HPGD | |
| SCHEMBL8341523 | 0.84 | L3MBTL1 (0.49) | KMT2AMEN1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL8338985 | 0.83 | ESR2 (0.56) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL29016416 | 0.81 | NPC1 (0.56) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL11681763 | 0.79 | ADRB2 (0.53) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL14811635 | 0.79 | KMT2A (0.61) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL8338192 | 0.78 | TP53 (0.56) | NPC1RAB9AKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5968975-A | TREATING ATHEROSCLEROSIS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1998057925-A1 | ELEVATION OF HDL CHOLESTEROL BY 2-[(AMINOTHIOXOMETHYL)-HYDRAZONO]-2-ARYLETHYL CARBAMATES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |