Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 11/20 | 0.56 |
| ▸ | THRA | P10827 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22106263 | 0.91 | LTA4H (0.55) | TERTTHRATHRBSIRT1HDAC3 | |
| SCHEMBL1916615 | 0.84 | POLB (0.56) | KDM4EMAPTTP53 | |
| SCHEMBL5779530 | 0.83 | MAPT (0.58) | KDM4EMAPTHRH3 | |
| SCHEMBL6004364 | 0.81 | TP53 (0.68) | THRBKDM4EMAPTHDAC3HDAC4 | |
| SCHEMBL14174770 | 0.81 | POLB (0.64) | TERTTHRATHRBSIRT1HDAC3 | |
| SCHEMBL11918281 | 0.80 | MAPT (0.53) | KDM4EMAPTTP53 | |
| SCHEMBL14216227 | 0.80 | TERT (0.59) | TERTTHRATHRBSIRT1HDAC3 | |
| SCHEMBL1429661 | 0.80 | TERT (0.59) | TERTTHRATHRBSIRT1MAPT | |
| SCHEMBL17633052 | 0.80 | HDAC2 (0.51) | THRATHRBSIRT1MAPTHDAC3 | |
| SCHEMBL10122853 | 0.80 | ICMT (0.60) | TERTMAPTHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |