SCHEMBL1916615

SCHEMBL1916615

O=Cc1ccc(NC(=O)CCC(=O)Nc2ccc(C=O)cc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.56
CYP1A1 P04798 1/20 0.53
KDM4E B2RXH2 2/20 0.51
MAPT P10636 2/20 0.51
TP53 P04637 1/20 0.50
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49
L3MBTL1 Q9Y468 2/20 0.48
ALDH1A1 P00352 1/20 0.47
HTT P42858 1/20 0.47
HPGD P15428 1/20 0.47
BCHE P06276 1/20 0.47
GAA P10253 1/20 0.46
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA4 P22748 1/20 0.46
CA9 Q16790 1/20 0.46
CA14 Q9ULX7 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5681335 0.93 POLB (0.69) POLBCYP1A1KDM4EMAPTTP53
SCHEMBL11918281 0.91 MAPT (0.53) POLBCYP1A1KDM4EMAPTTP53
SCHEMBL6004364 0.89 TP53 (0.68) KDM4EMAPTTP53MEN1KMT2A
SCHEMBL2739420 0.86 ALDH1A1 (0.59) KDM4EMAPTTP53MEN1KMT2A
SCHEMBL11918313 0.86 ALDH1A1 (0.66) POLBCYP1A1KDM4EMAPTMEN1
SCHEMBL10879959 0.84 PSMB11 (0.61) POLBKDM4EMAPTTP53MEN1
SCHEMBL8338992 0.84 TERT (0.56) KDM4EMAPTTP53
SCHEMBL6038006 0.84 NPC1 (0.59) POLBKDM4EMAPTMEN1KMT2A
SCHEMBL3732414 0.84 ALDH1A1 (0.44) POLBKDM4EMAPTTP53MEN1
SCHEMBL20195629 0.84 CA1 (0.56) POLBKDM4EMAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130018140-A1 N-BRIDGED POLYNITRONS AND THE USE THEREOF AS CROSS-LINKING AGENTS, IN PARTICULAR IN COATING MATERIALS AND ADHESIVES DICKMEIS MARCUS (DE) 2013-01-17 US disclosed
EP-2516531-A1 N-BRIDGED POLYNITRONS AND THE USE THEREOF AS CROSS-LINKERS, IN PARTICULAR IN COATING MATERIALS AND ADHESIVES Dickmeis, Marcus (DE) 2012-10-31 EP disclosed
WO-2011076392-A1 N-BRIDGED POLYNITRONS AND THE USE THEREOF AS CROSS-LINKERS, IN PARTICULAR IN COATING MATERIALS AND ADHESIVES DICKMEIS MARCUS (DE) 2011-06-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130018140-A1 N-BRIDGED POLYNITRONS AND THE USE THEREOF AS CROSS-LINKING AGENTS, IN PARTICULAR IN COATING MATERIALS AND ADHESIVES PNN, PARN, NCLN POLB 285/4885CYP1A1 979/4885KDM4E 2788/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.