Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 5/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8335037 | 0.76 | SOS1 (0.44) | SOS1HTR3ACCR3HTR6SLC6A2 | |
| SCHEMBL8339768 | 0.74 | KMT2A (0.41) | HTR3ADHFRMEN1KMT2A | |
| SCHEMBL8339061 | 0.68 | KMT2A (0.49) | MEN1KMT2A | |
| SCHEMBL10641373 | 0.66 | KDM4E (0.64) | KMT2A | |
| SCHEMBL20206661 | 0.66 | TDP1 (0.48) | KMT2A | |
| SCHEMBL8339799 | 0.66 | KMT2A (0.57) | KMT2A | |
| SCHEMBL6839501 | 0.65 | HTR1A (0.48) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8788970 | 0.65 | MCHR1 (0.48) | CCR3SLC6A4 | |
| SCHEMBL8336417 | 0.64 | HTR3E (0.53) | HTR3ACCR3DHFR | |
| SCHEMBL8337660 | 0.64 | DRD4 (0.43) | DHFRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889010-A | PSYCHOLOGICAL DISORDERS; UROGENITAL DISORDERS; COGNITION ACTIVATORS; NERVOUS SYSTEM DISORDERS; VISION DEFECTS; CONGESTIVE HEART FAILURE; DRUG ABRUSE; PARKINSON'S DISEASE;ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | PFIZER INC. (US) | 1999-03-30 | — | — | US | disclosed |