Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.48 |
| ▸ | DRD2 | P14416 | 6/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
| ▸ | PTAFR | P25105 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6839501 | 0.83 | HTR1A (0.48) | HTR1AHTR2ASLC6A4 | |
| SCHEMBL9053834 | 0.79 | DRD2 (0.50) | DRD2HTR1AHTR2ADRD3DRD1 | |
| SCHEMBL8340386 | 0.79 | HTR7 (0.57) | DRD2HTR1AHTR2ADRD3SIGMAR1 | |
| SCHEMBL8336417 | 0.79 | HTR3E (0.53) | HTR1ACCR3SIGMAR1 | |
| SCHEMBL8001944 | 0.78 | DRD2 (0.65) | DRD2HTR1AHTR2ADRD3DRD1 | |
| SCHEMBL8336244 | 0.78 | SIGMAR1 (0.52) | DRD2HTR1ASIGMAR1 | |
| SCHEMBL8787662 | 0.77 | SIGMAR1 (0.50) | DRD2HTR1APARP1PARP2SIGMAR1 | |
| SCHEMBL8011291 | 0.75 | DRD2 (0.65) | DRD2HTR1AHTR2ADRD3DRD1 | |
| SCHEMBL8339799 | 0.75 | KMT2A (0.57) | MCHR1 | |
| SCHEMBL8788615 | 0.75 | GRM2 (0.42) | DRD2HTR1AHTR2ADRD3DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775118-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1997-05-28 | — | — | EP | disclosed |