Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22965270 | 0.83 | TBXA2R (0.50) | KMT2ATSHRSMN1; SMN2KDM4EMAPT | |
| SCHEMBL11195213 | 0.82 | KMT2A (0.83) | KMT2ATSHRNUDT1BACE1CYP1A2 | |
| SCHEMBL8339061 | 0.82 | KMT2A (0.49) | KMT2ATSHRCYP1A2SMN1; SMN2RPS6KA5 | |
| SCHEMBL8336656 | 0.80 | LMNA (0.44) | KMT2ATSHRSMN1; SMN2KDM4ELMNA | |
| SCHEMBL8340061 | 0.80 | NUDT1 (0.46) | KMT2ATSHRNUDT1BACE1IRAK4 | |
| SCHEMBL10641373 | 0.80 | KDM4E (0.64) | KMT2ATSHRCYP1A2SMN1; SMN2RPS6KA5 | |
| SCHEMBL20206661 | 0.79 | TDP1 (0.48) | KMT2ASMN1; SMN2RPS6KA5KDM4ERAD52 | |
| SCHEMBL22965164 | 0.79 | FAAH (0.58) | KMT2ATSHRSMN1; SMN2RPS6KA5KDM4E | |
| SCHEMBL8336757 | 0.78 | LMNA (0.44) | KMT2ATSHRCYP1A2SMN1; SMN2RPS6KA5 | |
| SCHEMBL6231609 | 0.77 | KMT2A (0.51) | KMT2ATSHRIRAK4RPS6KA5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889010-A | PSYCHOLOGICAL DISORDERS; UROGENITAL DISORDERS; COGNITION ACTIVATORS; NERVOUS SYSTEM DISORDERS; VISION DEFECTS; CONGESTIVE HEART FAILURE; DRUG ABRUSE; PARKINSON'S DISEASE;ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | PFIZER INC. (US) | 1999-03-30 | — | — | US | disclosed |
| EP-0775118-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996004250-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1996-02-15 | — | — | WO | disclosed |