Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | GRM8 | O00222 | 1/20 | 0.35 |
| ▸ | GRM6 | O15303 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8339826 | 0.90 | KDM4E (0.42) | MAPTKDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL8335086 | 0.90 | CNR2 (0.36) | MAPTCYP1A2CYP2C19APPBCL2 | |
| SCHEMBL8336380 | 0.90 | MAPT (0.38) | MAPTKDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL8340536 | 0.88 | CNR2 (0.36) | MAPTMEN1CYP1A2CYP2C19KMT2A | |
| SCHEMBL8340639 | 0.88 | CNR2 (0.41) | MAPTKDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL8334595 | 0.86 | CNR2 (0.39) | MAPTMEN1CYP1A2CYP2C19KMT2A | |
| SCHEMBL8334344 | 0.86 | MAPT (0.38) | MAPTKDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL8339556 | 0.86 | MAPT (0.38) | MAPTKDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL8338716 | 0.85 | HTR1A (0.40) | MAPTKDM4EMEN1CYP1A2CYP2D6 | |
| SCHEMBL8340220 | 0.85 | PRKCZ (0.41) | PRKCZMAPTKDM4EMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948796-A | OSTEOPOROSIS, CANCER, CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 1999-09-07 | — | — | US | disclosed |