Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.34 |
| ▸ | GPR88 | Q9GZN0 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8335900 | 0.84 | TDP1 (0.46) | KDM4ECRHBPHTTCRHR2PKM | |
| SCHEMBL8335690 | 0.78 | MMP1 (0.36) | MMP1MMP9MMP13ADAM17GPR88 | |
| SCHEMBL8339931 | 0.78 | TDP1 (0.48) | KDM4ECRHBPHTTCRHR2MEN1 | |
| SCHEMBL8338140 | 0.70 | MMP9 (0.38) | MMP1MMP9MMP13ADAM17KDM4E | |
| SCHEMBL8334670 | 0.69 | MMP9 (0.41) | MMP1MMP9MMP13ADAM17KDM4E | |
| SCHEMBL8392500 | 0.69 | MMP9 (0.43) | MMP1MMP9MMP13ADAM17KDM4E | |
| SCHEMBL8336310 | 0.69 | MMP9 (0.43) | MMP1MMP9MMP13ADAM17KDM4E | |
| SCHEMBL8337813 | 0.68 | TDP1 (0.39) | GPR88KDM4ECRHBPCRHR2PKM | |
| SCHEMBL8338348 | 0.68 | TDP1 (0.39) | MMP1MMP9MMP13ADAM17GPR88 | |
| SCHEMBL8338207 | 0.66 | TDP1 (0.37) | MMP1MMP9MMP13ADAM17KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |