Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 5/20 | 0.31 |
| ▸ | MMP2 | P08253 | 5/20 | 0.31 |
| ▸ | MMP9 | P14780 | 4/20 | 0.31 |
| ▸ | MMP3 | P08254 | 2/20 | 0.31 |
| ▸ | MMP14 | P50281 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.31 |
| ▸ | MMP13 | P45452 | 2/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8340828 | 1.00 | KDM4E (0.36) | KDM4EALDH1A1LMNAMEN1HTT | |
| SCHEMBL8333962 | 0.99 | KDM4E (0.37) | KDM4EALDH1A1LMNAMEN1HTT | |
| SCHEMBL8334654 | 0.78 | MMP1 (0.46) | MMP1MMP2MMP9MMP3ADAM17 | |
| SCHEMBL8334941 | 0.77 | KMT2A (0.39) | KDM4EALDH1A1LMNAMEN1HTT | |
| SCHEMBL8340341 | 0.77 | KDM4E (0.36) | KDM4EALDH1A1LMNAMEN1HTT | |
| SCHEMBL8339878 | 0.74 | ALDH1A1 (0.33) | KDM4EALDH1A1LMNAMEN1HTT | |
| SCHEMBL8338863 | 0.73 | ALDH1A1 (0.35) | KDM4EALDH1A1LMNAMEN1HTT | |
| SCHEMBL8338337 | 0.73 | GAA (0.35) | KDM4EALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL8339028 | 0.70 | GAA (0.33) | KDM4EALDH1A1LMNAMEN1HTT | |
| SCHEMBL8334670 | 0.70 | MMP9 (0.41) | KDM4EHTTTDP1MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |