Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12809159 | 0.87 | PKM (0.49) | PKMHTTPOLBHSD17B1ALDH1A1 | |
| SCHEMBL385574 | 0.81 | PKM (0.75) | PKMHTTPOLBHSD17B1KMT2A | |
| SCHEMBL10061495 | 0.81 | PRKCI (0.53) | PKMHTTPOLBKMT2AALDH1A1 | |
| SCHEMBL8845203 | 0.79 | PKM (0.72) | PKMHTTPOLBHSD17B1KMT2A | |
| SCHEMBL9574305 | 0.79 | PKM (1.00) | PKMHTTPOLBHSD17B1KMT2A | |
| SCHEMBL29291399 | 0.78 | PKM (0.70) | PKMHTTPOLBHSD17B1KMT2A | |
| SCHEMBL469648 | 0.78 | PKM (0.70) | PKMHTTPOLBHSD17B1KMT2A | |
| SCHEMBL10743832 | 0.78 | PKM (0.70) | PKMHTTPOLBHSD17B1KMT2A | |
| SCHEMBL28973935 | 0.78 | PKM (0.55) | PKMHTTPOLBHSD17B1KMT2A | |
| SCHEMBL11552891 | 0.77 | PKM (0.64) | PKMHTTPOLBHSD17B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024728-A2 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | disclosed |