Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 4/20 | 0.66 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | RXRG | P48443 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873463 | 0.88 | MMP12 (0.71) | MMP12NR1H4MMP2MMP8MMP13 | |
| SCHEMBL8340728 | 0.86 | MMP12 (0.64) | MMP12NR1H4SMN1; SMN2PPARGPPARA | |
| SCHEMBL8341227 | 0.84 | MMP12 (0.77) | MMP12SMN1; SMN2HPGDMMP2MMP8 | |
| SCHEMBL6878974 | 0.79 | MMP12 (0.55) | MMP12SMN1; SMN2MMP2MMP8MMP13 | |
| SCHEMBL6875476 | 0.78 | MMP12 (0.71) | MMP12NR1H4MMP13RXRARXRB | |
| SCHEMBL6874687 | 0.77 | MMP12 (0.83) | MMP12SMN1; SMN2PPARGPPARAHPGD | |
| SCHEMBL8339276 | 0.77 | MMP12 (0.75) | MMP12NR1H4SMN1; SMN2RXRARXRB | |
| SCHEMBL6880697 | 0.76 | MMP12 (0.78) | MMP12NR1H4MMP8MMP13LMNA | |
| SCHEMBL6450538 | 0.76 | MMP12 (0.69) | MMP12NR1H4SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL6882200 | 0.75 | MMP12 (0.50) | MMP12SMN1; SMN2PPARGPPARAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534700-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004018448-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2004-03-04 | — | — | WO | disclosed |