Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAP | Q12884 | 2/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | PREP | P48147 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8486131 | 0.84 | EPHX2 (0.44) | EPHX2ALDH1A1JUNCDK2MAPK8 | |
| SCHEMBL23573320 | 0.83 | EPHX2 (0.45) | FAPDPP4PREPEPHX2ALDH1A1 | |
| SCHEMBL20124162 | 0.82 | SMN1; SMN2 (0.41) | EPHX2ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL12436977 | 0.81 | FAP (0.46) | FAPDPP4PREPALDH1A1MEN1 | |
| SCHEMBL14115757 | 0.81 | GNAI3 (0.49) | FAPDPP4PREPALDH1A1MEN1 | |
| SCHEMBL24272052 | 0.79 | L3MBTL1 (0.47) | FAPDPP4PREPALDH1A1MEN1 | |
| SCHEMBL8485640 | 0.78 | EPHX2 (0.45) | EPHX2ALDH1A1NPC1EPHX1 | |
| SCHEMBL12507086 | 0.78 | EPHX2 (0.62) | EPHX2EPHX1 | |
| SCHEMBL4757596 | 0.78 | FAP (0.44) | FAPDPP4PREPALDH1A1MEN1 | |
| SCHEMBL17642627 | 0.78 | FAP (0.44) | FAPDPP4PREPALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024728-A2 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | disclosed |