Sugi Predict

Sugi Predict / Compounds / Ethylmalonate

Ethylmalonate

Ethylmalonate

SCHEMBL83437

CCC(C(=O)O)C(=O)O.[KH]

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HDAC1 Q13547 2/20 0.43
▸ HDAC2 Q92769 2/20 0.43
▸ CHRM1 P11229 1/20 0.43
▸ AKR1A1 P14550 1/20 0.43
▸ CHRM3 P20309 1/20 0.43
▸ HTR2A P28223 1/20 0.43
▸ HTR2C P28335 1/20 0.43
▸ ADRA1A P35348 1/20 0.43
▸ HRH1 P35367 1/20 0.43
▸ DRD3 P35462 1/20 0.43
▸ SLC6A3 Q01959 1/20 0.43
▸ TDP1 Q9NUW8 1/20 0.43
▸ CA2 P00918 1/20 0.42
▸ MAPK1 P28482 1/20 0.42
▸ FFAR3 O14843 2/20 0.41
▸ SLC1A3 P43003 1/20 0.40
▸ SLC1A2 P43004 1/20 0.40
▸ SLC1A1 P43005 1/20 0.40
▸ TP53 P04637 1/20 0.39
▸ MEN1 O00255 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethylmalonate SCHEMBL28314706 0.97 HDAC1 (0.41) HDAC1HDAC2CHRM1AKR1A1CHRM3
Ethylmalonate SCHEMBL28315792 0.97 HDAC1 (0.41) HDAC1HDAC2CHRM1AKR1A1CHRM3
Ethylmalonate SCHEMBL107241 0.96 — —
Ethylmalonate SCHEMBL108039 0.93 HDAC1 (0.43) HDAC1HDAC2CHRM1AKR1A1CHRM3
Ethylmalonate SCHEMBL9765245 0.93 HDAC1 (0.43) HDAC1HDAC2CHRM1AKR1A1CHRM3
Ethylmalonate SCHEMBL29018396 0.93 HDAC1 (0.43) HDAC1HDAC2CHRM1AKR1A1CHRM3
Ethylmalonate SCHEMBL9118935 0.93 HDAC1 (0.43) HDAC1HDAC2CHRM1AKR1A1CHRM3
Ethylmalonate SCHEMBL3157979 0.93 HDAC1 (0.43) HDAC1HDAC2CHRM1AKR1A1CHRM3
Ethylmalonate SCHEMBL108554 0.93 HDAC1 (0.43) HDAC1HDAC2CHRM1AKR1A1CHRM3
Ethylmalonate SCHEMBL5236397 0.93 HDAC1 (0.43) HDAC1HDAC2CHRM1AKR1A1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 306 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118320360-A Easily-decomposed high-performance fire extinguishing coolant for aerosol fire extinguishing agent 湖北及安盾消防科技有限公司 2024-07-12 — — CN claimed
CN-115938640-A Acetic acid resistant solar cell silver paste and preparation method thereof 江西佳银科技有限公司 2023-04-07 — — CN claimed
CN-112358396-A Preparation process of ethyl isobutyrylacetate 门希国 2021-02-12 — — CN claimed
CN-110172019-A The metal salt of malonic acid as the nucleating additive for crystalline thermoplastic 印度石油有限公司 2019-08-27 — — CN claimed
US-20190256683-A1 METAL SALTS OF MALONIC ACID AS NUCLEATING ADDITIVES FOR CRYSTALLINE THERMOPLASTICS INDIAN OIL CORPORATION LIMITED (IN) 2019-08-22 — — US claimed
EP-3527616-A1 METAL SALTS OF MALONIC ACID AS NUCLEATING ADDITIVES FOR CRYSTALLINE THERMOPLASTICS INDIAN OIL CORPORATION Ltd. (IN) 2019-08-21 — — EP claimed
EP-2190804-B1 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS GILEAD SCIENCES INC (US) 2015-11-18 — — EP claimed
US-8324244-B2 Process and intermediates for preparing integrase inhibitors GILEAD SCIENCES, INC. (US) 2012-12-04 — — US claimed
US-8153801-B2 Process and intermediates for preparing integrase inhibitors GILEAD SCIENCES, INC. (US) 2012-04-10 — — US claimed
US-20110160458-A1 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS GILEAD SCIENCES, INC. (US) 2011-06-30 — — US claimed
EP-2190804-A1 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS Gilead Sciences, Inc. (US) 2010-06-02 — — EP claimed
EP-2069280-A2 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS Gilead Sciences, Inc. (US) 2009-06-17 — — EP claimed
US-20090099366-A1 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS GILEAD SCIENCES, INC. (US) 2009-04-16 — — US claimed
WO-2009036161-A1 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS GILEAD SCIENCES, INC. (US) 2009-03-19 — — WO claimed
US-20080161560-A1 Process for Preparation of Calcium Salt of Rosuvastatin DESHPANDE PANDURANG BALWANT 2008-07-03 — — US claimed
WO-2008033836-A2 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS GILEAD SCIENCES, INC. (US) 2008-03-20 — — WO claimed
EP-1869005-A1 PROCESS FOR PREPARATION OF CALCIUM SALT OF ROSUVASTATIN UNICHEM LABORATORIES LIMITED (IN) 2007-12-26 — — EP claimed
WO-2006106526-A1 PROCESS FOR PREPARATION OF CALCIUM SALT OF ROSUVASTATIN UNICHEM LABORATORIES LIMITED (IN) 2006-10-12 — — WO claimed
CN-1092191-C Manufacture of cyclocarbonates HOFFMANN LA ROCHE (CH) 2002-10-09 — — CN claimed
CN-1180703-A Manufacture of cyclocarbonates HOFFMANN LA ROCHE (CH) 1998-05-06 — — CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190256683-A1 METAL SALTS OF MALONIC ACID AS NUCLEATING ADDITIVES FOR CRYSTALLINE THERMOPLASTICS NUMA1, MNS1, ME1 HDAC1 779/4885HDAC2 2333/4885CHRM1 4107/4885
US-20090099366-A1 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS TYMS, TYMP, POLB HDAC1 3192/4885HDAC2 2720/4885CHRM1 4604/4885
US-20080161560-A1 Process for Preparation of Calcium Salt of Rosuvastatin CACNA1C, CACNA1E, CACNA1S HDAC1 2004/4885HDAC2 2210/4885CHRM1 2758/4885
US-20110160458-A1 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS TYMS, TYMP, POLB HDAC1 3192/4885HDAC2 2720/4885CHRM1 4604/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.