Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 3/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8344343 | 0.87 | LATS1 (0.43) | LATS1MAPK14TGFBR1CYP1A2CYP3A4 | |
| SCHEMBL8348074 | 0.87 | TGFBR1 (0.57) | LATS1MAPK14TGFBR1CYP1A2CYP3A4 | |
| SCHEMBL8347042 | 0.85 | LMNA (0.46) | LATS1MAPK14TGFBR1CYP1A2CYP3A4 | |
| SCHEMBL8348078 | 0.85 | LATS1 (0.56) | LATS1CYP1A2CYP3A4CYP2C19LMNA | |
| SCHEMBL8345669 | 0.80 | CYP1A2 (0.50) | MAPK14TGFBR1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL18114540 | 0.78 | ROCK2 (0.43) | PIK3CA | |
| SCHEMBL8347942 | 0.77 | CYP1A2 (0.64) | MAPK14TGFBR1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL8345684 | 0.77 | TGFBR1 (0.63) | TGFBR1CYP1A2CYP3A4CYP2C19LMNA | |
| SCHEMBL8348077 | 0.76 | CYP1A2 (0.64) | CYP1A2CYP3A4CYP2C19LMNACYP2D6 | |
| SCHEMBL8344336 | 0.74 | CYP1A2 (0.60) | MAPK14TGFBR1CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |