Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 7/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8347942 | 0.88 | CYP1A2 (0.64) | CYP1A2CYP3A4ALDH1A1LMNAHSD17B10 | |
| SCHEMBL8344336 | 0.84 | CYP1A2 (0.60) | CYP1A2CYP3A4ALDH1A1LMNAHSD17B10 | |
| SCHEMBL8345684 | 0.84 | TGFBR1 (0.63) | CYP1A2CYP3A4ALDH1A1LMNAHSD17B10 | |
| SCHEMBL8344524 | 0.83 | LMNA (0.55) | CYP1A2CYP3A4ALDH1A1LMNAHSD17B10 | |
| SCHEMBL8345584 | 0.82 | BUB1 (0.50) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL8348074 | 0.81 | TGFBR1 (0.57) | CYP1A2CYP3A4ALDH1A1LMNAHSD17B10 | |
| SCHEMBL8344331 | 0.80 | LATS1 (0.47) | CYP1A2CYP3A4ALDH1A1LMNAHSD17B10 | |
| SCHEMBL8347042 | 0.77 | LMNA (0.46) | CYP1A2CYP3A4ALDH1A1LMNAHSD17B10 | |
| SCHEMBL18114582 | 0.77 | ROCK2 (0.51) | TGFBR1 | |
| SCHEMBL14344357 | 0.75 | TGFBR1 (0.72) | CYP1A2CYP3A4ALDH1A1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |