Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | PPIA | P62937 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011352 | 0.88 | FOLH1 (0.47) | ALDH1A1MAPTL3MBTL1TDP1PLA2G1B | |
| SCHEMBL7011022 | 0.88 | KDM4E (0.44) | KDM4EALDH1A1GAAHPGDKMT2A | |
| SCHEMBL9080973 | 0.84 | KMT2A (0.41) | KDM4EALDH1A1GAAHPGDKMT2A | |
| SCHEMBL7014263 | 0.82 | PLA2G1B (0.39) | KDM4EALDH1A1GAAMAPTLMNA | |
| SCHEMBL3952696 | 0.80 | RXRA (0.49) | MAPTL3MBTL1TDP1PLA2G1BMAPK1 | |
| SCHEMBL13794527 | 0.79 | MAPT (0.45) | ALDH1A1GAAHPGDMAPTPPIA | |
| SCHEMBL7014122 | 0.77 | PLA2G1B (0.53) | PLA2G1B | |
| SCHEMBL11070583 | 0.75 | KDM4E (0.52) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL2582045 | 0.74 | RXRA (0.54) | KDM4EKMT2AMAPTSMN1; SMN2PPIA | |
| SCHEMBL8323146 | 0.73 | CA12 (0.64) | KDM4EGAAKMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999024033-A1 | METHOD FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH APOPTOSIS USING N-HETEROCYCLIC GLYOXYLAMIDE COMPOUNDS | SHIONOGI & CO., LTD. (JP) | 1999-05-20 | — | — | WO | disclosed |
| WO-1998047507-A1 | METHOD FOR THE TREATMENT OF STROKE USING N-HETEROCYCLIC GLYOXYLAMIDE COMPOUNDS | SHIONOGI & CO., LTD. (JP) | 1998-10-29 | — | — | WO | disclosed |