Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429170 | 0.93 | LMNA (0.67) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL6195822 | 0.88 | LMNA (1.00) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL4422567 | 0.86 | LMNA (0.79) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL29624123 | 0.85 | KMT2A (0.72) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL9365789 | 0.85 | KMT2A (0.72) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL8342494 | 0.84 | LMNA (0.75) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL9369551 | 0.83 | SMN1; SMN2 (0.58) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL7340898 | 0.82 | LMNA (0.76) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL4431508 | 0.80 | LMNA (0.54) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL9366734 | 0.80 | LMNA (0.54) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939435-A | TREATMENT OF ATHEROSCLEROSIS AND CORONARY HEART DISEASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-17 | — | — | US | disclosed |
| WO-1999012857-A1 | REFLECTIVE PORCELAIN ENAMEL COATING COMPOSITION | FERRO CORPORATION (US) | 1999-03-18 | — | — | WO | disclosed |