Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429170 | 0.86 | LMNA (0.67) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL4422567 | 0.82 | LMNA (0.79) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9369551 | 0.82 | SMN1; SMN2 (0.58) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9366963 | 0.82 | ALDH1A1 (0.67) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8345917 | 0.80 | LMNA (0.78) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9365789 | 0.79 | KMT2A (0.72) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9366700 | 0.76 | MEN1 (0.52) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL4429146 | 0.76 | LMNA (0.65) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL4418569 | 0.71 | MEN1 (0.51) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9365765 | 0.70 | LMNA (0.44) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553967-B2 | 1,2-Dihydroquinoline derivatives and method for using the same to treat HIV infections | WYETH (US) | 2009-06-30 | — | — | US | claimed |
| US-20050203129-A1 | 1, 2-Dihydroquinoline derivatives and method for using the same to treat HIV infections | WYETH | 2005-09-15 | — | — | US | claimed |
| WO-2005051381-A1 | Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R) | BIOVITRUM AB (SE) | 2005-06-09 | — | — | WO | claimed |
| US-7553967-B2 | 1,2-Dihydroquinoline derivatives and method for using the same to treat HIV infections | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
| WO-2005090309-A1 | 1,2-DIHYDROQUINOLINE DERIVATIVES AND METHOD FOR USING THE SAME TO TREAT HIV INFECTION | WYETH (US) | 2005-09-29 | — | — | WO | disclosed |
| US-20050203129-A1 | 1, 2-Dihydroquinoline derivatives and method for using the same to treat HIV infections | WYETH | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203129-A1 | 1, 2-Dihydroquinoline derivatives and method for using the same to treat HIV infections | CBR3, CBR1, NR1H3 | LMNA 4140/4885SMN1; SMN2 4136/4885ALDH1A1 924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.