Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 13/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.39 |
| ▸ | BUB1 | O43683 | 6/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.38 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8347946 | 0.91 | FLT1 (0.43) | TGFBR1PRKD3PRKD1PRKD2TGFBR2 | |
| SCHEMBL8344966 | 0.90 | TGFBR1 (0.39) | TGFBR1PRKD3PRKD1PRKD2TGFBR2 | |
| SCHEMBL8344951 | 0.88 | AGER (0.39) | TGFBR1PRKD3PRKD1PRKD2TGFBR2 | |
| SCHEMBL8347168 | 0.88 | TGFBR1 (0.47) | TGFBR1PRKD3PRKD1PRKD2TGFBR2 | |
| SCHEMBL8348247 | 0.87 | FLT1 (0.41) | TGFBR1PRKD3PRKD1PRKD2TGFBR2 | |
| SCHEMBL8348227 | 0.87 | FGFR1 (0.46) | TGFBR1BUB1ACVR1B | |
| SCHEMBL8344954 | 0.86 | PTGER1 (0.42) | TGFBR1PRKD3PRKD1PRKD2TGFBR2 | |
| SCHEMBL8344535 | 0.85 | TGFBR1 (0.41) | TGFBR1PRKD3PRKD1PRKD2TGFBR2 | |
| SCHEMBL8346012 | 0.85 | TGFBR1 (0.56) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8344360 | 0.84 | HPGD (0.41) | TGFBR1TGFBR2BUB1ACVRL1ACVR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |