Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460365 | 0.91 | OPRL1 (0.57) | MEN1KMT2AOPRL1CCR3POLB | |
| SCHEMBL8349645 | 0.89 | CCR3 (0.61) | MEN1KMT2AOPRL1CCR3POLB | |
| Hydrochloric Acid SCHEMBL8347459 | 0.88 | ALDH1A1 (0.45) | CACNA1GMEN1KMT2APOLBCYP2D6 | |
| SCHEMBL8347345 | 0.88 | LMNA (0.52) | MEN1KMT2AOPRL1CCR3POLB | |
| SCHEMBL8349949 | 0.87 | POLB (0.55) | OPRL1POLBMAPK1 | |
| SCHEMBL2702170 | 0.85 | ALDH1A1 (0.55) | CACNA1GMEN1KMT2AOPRL1CCR3 | |
| SCHEMBL373427 | 0.84 | SLC6A12 (0.53) | CACNA1GMEN1KMT2ACYP2D6MAPK1 | |
| SCHEMBL8347214 | 0.81 | CACNA1G (0.48) | CACNA1GMEN1KMT2AOPRL1CCR3 | |
| SCHEMBL10924212 | 0.81 | SLC6A12 (0.53) | MEN1KMT2AOPRL1POLBCYP2D6 | |
| SCHEMBL7463193 | 0.78 | OPRL1 (0.46) | MEN1KMT2AOPRL1CCR3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861416-A | TREATMENT OF ASTHMA OR COUGH | MERRELL PHARMACEUTICALS INC. (US) | 1999-01-19 | — | — | US | disclosed |
| US-5824690-A | TREATING ASTHMA, COUGH | HOECHST MARION ROUSSEL INC. (US) | 1998-10-20 | — | — | US | disclosed |
| US-5661160-A | ADMINISTERING AN ANTITUSSIVE AGENT FOR TREATING COUGH; TACHYKININ ANTAGONISM, SUBSTANCE P AND NEUROKININ A ANTAGONISM | MERRELL PHARMACEUTICALS INC. (US) | 1997-08-26 | — | — | US | disclosed |
| US-5648366-A | TACHYKININ ANTAGONISTS USEFUL IN TREATING ASTHMA | MERRELL PHARMACEUTICALS INC. (US) | 1997-07-15 | — | — | US | disclosed |
| US-5635510-A | TACHYKININ (ESPECIALLY SUBSTANCE P AND NEUROKININ A) ANTAGONISTS; ANTIINFLAMMATORY AGENTS, ANALGESICS; NERVOUS SYSTEM DISORDERS; BRONCHODILATOR AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1997-06-03 | — | — | US | disclosed |