Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 6/20 | 0.43 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | SCN7A | Q01118 | 5/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8461585 | 0.87 | PDE10A (0.50) | LTB4RPDE10A | |
| SCHEMBL8465133 | 0.81 | CYP19A1 (0.55) | MAOBCYP19A1PDE4D | |
| SCHEMBL8465603 | 0.76 | MAOB (0.46) | LTB4RMAOBCYP19A1PDE4D | |
| SCHEMBL8465764 | 0.76 | LTB4R (0.53) | LTB4RMAOBPDE10A | |
| SCHEMBL8465611 | 0.75 | MAOB (0.55) | MAOBCYP19A1 | |
| SCHEMBL14480625 | 0.74 | SCN9A (0.52) | MAOBKCNH2PDE4DSCN5ASCN2A | |
| SCHEMBL8466345 | 0.73 | LTB4R (0.66) | LTB4RCYP19A1PDE10A | |
| SCHEMBL8464260 | 0.73 | LTB4R (0.66) | LTB4RCYP19A1PDE10A | |
| SCHEMBL8464264 | 0.73 | LTB4R (0.66) | LTB4RCYP19A1PDE10A | |
| SCHEMBL14552636 | 0.72 | CYP19A1 (0.43) | LTB4RMAOBCYP19A1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952326-A | Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1999-09-14 | — | — | US | disclosed |
| US-5698550-A | Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1997-12-16 | — | — | US | disclosed |
| EP-0441515-B1 | Tetralin and chroman derivatives in the treatment of asthma, arthritis and related diseases | PFIZER (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1991012253-A1 | TETRALIN AND CHROMAN DERIVATIVES USEFUL IN THE TREATMENT OF ASTHMA, ARTHRITIS, AND RELATED DISEASES | PFIZER INC. (US) | 1991-08-22 | — | — | WO | disclosed |
| EP-0441515-A1 | Tetralin and chroman derivatives in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |