Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.51 |
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 13/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8347622 | 0.88 | CTSK (0.55) | CTSKCTSSCTSLACEACE2 | |
| SCHEMBL5941507 | 0.86 | CTSK (0.67) | CTSKCTSSCTSLACEACE2 | |
| SCHEMBL5941511 | 0.86 | CTSK (0.67) | CTSKCTSSCTSLACEACE2 | |
| SCHEMBL6209627 | 0.85 | CHRNB2 (0.42) | CTSKCTSSCTSLHCRTR1HCRTR2 | |
| SCHEMBL4217173 | 0.84 | CTSK (0.57) | CTSKCTSSCTSLACEACE2 | |
| SCHEMBL4217170 | 0.84 | CTSK (0.57) | CTSKCTSSCTSLACEACE2 | |
| SCHEMBL5942475 | 0.84 | CTSK (0.57) | CTSKCTSSCTSLACEACE2 | |
| SCHEMBL13909143 | 0.84 | CTSK (0.52) | CTSKCTSSCTSL | |
| SCHEMBL8349386 | 0.84 | CTSK (0.52) | CTSKCTSSCTSLACEACE2 | |
| SCHEMBL6210598 | 0.84 | CTSL (0.45) | CTSKCTSSCTSLACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |