Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | CTSS | P25774 | 3/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
| ▸ | GPR132 | Q9UNW8 | 4/20 | 0.34 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.34 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.34 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6212077 | 0.91 | CTSL (0.39) | CTSKCTSSCTSLCYP51A1PREP | |
| SCHEMBL8348202 | 0.85 | CTSK (0.51) | CTSKCTSSCTSLACEHCRTR1 | |
| SCHEMBL4046533 | 0.83 | MAPK1 (0.36) | CTSKCTSSCYP51A1ACEACE2 | |
| SCHEMBL4043376 | 0.83 | CTSK (0.56) | CHRNB2CHRNA4CTSKCTSSACE | |
| SCHEMBL4049549 | 0.80 | GPR132 (0.38) | CTSKCTSSACEACE2GPR132 | |
| SCHEMBL4043491 | 0.80 | DPP4 (0.48) | — | |
| SCHEMBL6210816 | 0.79 | CTSL (0.43) | CTSKCTSSCTSLHCRTR1HCRTR2 | |
| SCHEMBL6209046 | 0.79 | CTSK (0.47) | CTSKCTSSCTSLCYP51A1ACE | |
| SCHEMBL4046323 | 0.78 | CTSK (0.54) | CTSKCTSSCTSLCYP51A1ACE | |
| SCHEMBL6210598 | 0.77 | CTSL (0.45) | CTSKCTSSCTSLPREPACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |