Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.46 |
| ▸ | FLT1 | P17948 | 4/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | FLT4 | P35916 | 3/20 | 0.41 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BUB1 | O43683 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | BAD | Q92934 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8345668 | 0.87 | TGFBR1 (0.40) | TGFBR1BUB1ACVR1B | |
| SCHEMBL8347946 | 0.86 | FLT1 (0.43) | FGFR1FLT1KDRTGFBR1EGFR | |
| SCHEMBL8344360 | 0.84 | HPGD (0.41) | KDRTGFBR1BUB1ACVR1B | |
| SCHEMBL8344966 | 0.84 | TGFBR1 (0.39) | FLT1KDRTGFBR1EGFRBUB1 | |
| SCHEMBL8344951 | 0.83 | AGER (0.39) | FGFR1FLT1KDRTGFBR1EGFR | |
| SCHEMBL8347168 | 0.83 | TGFBR1 (0.47) | FLT1TGFBR1EGFRBUB1ACVR1B | |
| SCHEMBL8348942 | 0.82 | KDR (0.53) | FGFR1FLT1KDRTGFBR1AXL | |
| SCHEMBL8348247 | 0.81 | FLT1 (0.41) | FLT1KDRTGFBR1BUB1ACVR1B | |
| SCHEMBL8344954 | 0.81 | PTGER1 (0.42) | FLT1KDRTGFBR1BUB1ACVR1B | |
| SCHEMBL8344535 | 0.80 | TGFBR1 (0.41) | TGFBR1ACVR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |