Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TACR2 | P21452 | 3/20 | 0.39 |
| ▸ | TACR1 | P25103 | 3/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640835 | 0.91 | HRH1 (0.42) | ALDH1A1LMNATSHRUSP2SMN1; SMN2 | |
| SCHEMBL8634965 | 0.88 | CYP3A4 (0.46) | ALDH1A1LMNACYP3A4CYP1A2CYP2C19 | |
| SCHEMBL8355592 | 0.88 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2CYP1A2TACR2TACR1 | |
| SCHEMBL8353688 | 0.85 | KDM4E (0.46) | ALDH1A1CYP3A4CYP1A2CYP2C19TACR2 | |
| SCHEMBL8636055 | 0.85 | PKM (0.43) | ALDH1A1CYP3A4CYP1A2CYP2C19TACR2 | |
| SCHEMBL8636037 | 0.85 | PKM (0.51) | ALDH1A1CYP1A2 | |
| SCHEMBL8640612 | 0.84 | ALDH1A1 (0.41) | ALDH1A1LMNASMN1; SMN2CYP1A2TACR2 | |
| SCHEMBL8641320 | 0.84 | ALDH1A1 (0.52) | ALDH1A1CYP1A2TACR2TACR1TACR3 | |
| SCHEMBL8350201 | 0.83 | LMNA (0.44) | ALDH1A1LMNACYP1A2HRH1 | |
| SCHEMBL8636579 | 0.83 | TACR2 (0.46) | CYP3A4CYP2C19TACR2TACR1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861416-A | TREATMENT OF ASTHMA OR COUGH | MERRELL PHARMACEUTICALS INC. (US) | 1999-01-19 | — | — | US | disclosed |
| US-5824690-A | TREATING ASTHMA, COUGH | HOECHST MARION ROUSSEL INC. (US) | 1998-10-20 | — | — | US | disclosed |