Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | EDNRB | P24530 | 5/20 | 0.45 |
| ▸ | EDNRA | P25101 | 5/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzenesulfonamide SCHEMBL7866959 | 0.94 | PTGS2 (0.63) | PTGS2ALDH1A1NPSR1MT-CO2PKM | |
| SCHEMBL8597059 | 0.90 | PTGS2 (0.45) | PTGS2ALDH1A1NPSR1MT-CO2PKM | |
| SCHEMBL8476337 | 0.90 | ALDH1A1 (0.49) | PTGS2ALDH1A1NPSR1MT-CO2PKM | |
| SCHEMBL8475895 | 0.88 | PTGS2 (0.54) | PTGS2ALDH1A1NPSR1MT-CO2PKM | |
| SCHEMBL8477416 | 0.87 | ALDH1A1 (0.47) | PTGS2ALDH1A1NPSR1MT-CO2PKM | |
| SCHEMBL8473431 | 0.86 | ALDH1A1 (0.51) | PTGS2ALDH1A1NPSR1MT-CO2PKM | |
| SCHEMBL8474218 | 0.85 | ALDH1A1 (0.50) | PTGS2ALDH1A1NPSR1MT-CO2PKM | |
| SCHEMBL8473748 | 0.84 | ALDH1A1 (0.45) | PTGS2ALDH1A1NPSR1MT-CO2PKM | |
| SCHEMBL8478927 | 0.84 | ALDH1A1 (0.49) | PTGS2ALDH1A1NPSR1MT-CO2PKM | |
| SCHEMBL8479939 | 0.84 | ALDH1A1 (0.49) | PTGS2ALDH1A1NPSR1MT-CO2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0941080-A2 | METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS AS ANTI-ANGIOGENIC AGENTS | G.D. SEARLE & CO. (US) | 1999-09-15 | — | — | EP | disclosed |
| US-5932598-A | NOVEL SUBSTITUTED SULFONAMIDE COMPOUNDS USEFUL AS PRODRUGS; ADMINISTERING TO TREAT INFLAMMATION-ASSOCIATED PAIN DUE TO CANCER, DENTAL PAIN; CYCLOOXYGENASE-2 INHIBITORS | G. D. SEARLE & CO. (US) | 1999-08-03 | — | — | US | disclosed |
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1998022101-A2 | METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS AS ANTI-ANGIOGENIC AGENTS | G.D. SEARLE & CO. (US) | 1998-05-28 | — | — | WO | disclosed |