Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.37 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 3/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8289776 | 0.87 | F2 (0.38) | SSTR4GRM2MEN1KMT2ACHRM5 | |
| SCHEMBL28836938 | 0.85 | SSTR4 (0.38) | SSTR4MLYCDMEN1KMT2AF2 | |
| SCHEMBL3657533 | 0.85 | MT-CO2 (0.46) | SSTR4MLYCDMEN1KMT2AF2 | |
| SCHEMBL1624311 | 0.84 | SMN1; SMN2 (0.51) | SSTR4MEN1KMT2ACHRM1CHRM3 | |
| SCHEMBL19317380 | 0.82 | F2 (0.50) | SSTR4MLYCDMEN1KMT2AF2 | |
| SCHEMBL3349318 | 0.82 | MLYCD (0.41) | MLYCDMEN1KMT2AKCNQ4KCNQ5 | |
| SCHEMBL12497490 | 0.81 | ALDH1A1 (0.41) | SSTR4KMT2ACYP3A4LMNAHTT | |
| SCHEMBL9222980 | 0.81 | KCNQ4 (0.41) | SSTR4GRM2MEN1KMT2AKCNQ4 | |
| SCHEMBL1346906 | 0.78 | SSTR4 (0.46) | SSTR4GRM2F2LMNANPSR1 | |
| SCHEMBL4744310 | 0.77 | SSTR4 (0.56) | SSTR4GRM2KCNQ4KCNQ5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480545-A1 | FUSED TRIAZOLE AMINES AS P2X7 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2012-08-01 | — | — | EP | disclosed |
| WO-2011033055-A1 | FUSED TRIAZOLE AMINES AS P2X7 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-24 | — | — | WO | disclosed |