Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8357277 | 0.90 | USP2 (0.69) | USP2KMT2AGFERLMNAMAPT | |
| SCHEMBL8356301 | 0.81 | MAPT (0.57) | USP2KMT2ALMNAMAPTTSHR | |
| SCHEMBL8353727 | 0.81 | ALDH1A1 (0.62) | USP2KMT2ALMNAMAPTTSHR | |
| SCHEMBL8354273 | 0.80 | USP2 (0.69) | USP2KMT2AGFERLMNAMAPT | |
| SCHEMBL8356307 | 0.76 | MAPT (0.55) | USP2KMT2ALMNAMAPTTSHR | |
| SCHEMBL8350371 | 0.72 | SLC27A1 (0.68) | KMT2ALMNAALDH1A1MEN1KDM4E | |
| SCHEMBL8352629 | 0.72 | MAPT (0.59) | USP2KMT2ALMNAMAPTTSHR | |
| SCHEMBL8351229 | 0.71 | GLS (0.58) | LMNAMAPTTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL8353646 | 0.71 | MEN1 (0.63) | USP2KMT2AGFERLMNAMAPT | |
| SCHEMBL15401066 | 0.71 | KDR (0.74) | USP2KMT2ALMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | claimed |
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |