Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8357277 | 0.82 | USP2 (0.69) | USP2KMT2ALMNAL3MBTL1MEN1 | |
| SCHEMBL8350090 | 0.80 | USP2 (0.67) | USP2KMT2ALMNAL3MBTL1MEN1 | |
| SCHEMBL8350364 | 0.78 | LMNA (0.69) | USP2KMT2ALMNAL3MBTL1PKM | |
| SCHEMBL8357279 | 0.77 | ALDH1A1 (0.69) | USP2KMT2ALMNASMN1; SMN2TSHR | |
| SCHEMBL8358213 | 0.77 | KDM4E (0.74) | KMT2ALMNAL3MBTL1PKMMEN1 | |
| SCHEMBL8350371 | 0.75 | SLC27A1 (0.68) | KMT2ALMNAMEN1ALDH1A1 | |
| SCHEMBL15401066 | 0.73 | KDR (0.74) | USP2KMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL8809227 | 0.72 | MEN1 (0.65) | KMT2ALMNAL3MBTL1MEN1GFER | |
| SCHEMBL977214 | 0.72 | LMNA (0.68) | USP2KMT2ALMNAL3MBTL1MEN1 | |
| SCHEMBL6372797 | 0.72 | RAB9A (0.79) | KMT2ALMNAMEN1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | claimed |
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |