Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.68 |
| ▸ | TSHR | P16473 | 6/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350338 | 0.89 | MAPT (0.55) | MAPTTSHRLMNAMAPK10MAPK1 | |
| SCHEMBL8358322 | 0.76 | TSHR (0.71) | MAPTTSHRLMNAMAPK10MAPK1 | |
| SCHEMBL8358036 | 0.75 | POLB (0.72) | MAPTTSHRLMNAMAPK10MAPK1 | |
| SCHEMBL31531433 | 0.74 | MAPK10 (0.69) | MAPTTSHRLMNAMAPK10MAPK1 | |
| SCHEMBL8354074 | 0.74 | MAPT (0.68) | MAPTTSHRLMNAMAPK10MAPK1 | |
| Hydrochloric Acid SCHEMBL8351225 | 0.73 | MAPT (0.67) | MAPTTSHRLMNAMAPK10MAPK1 | |
| SCHEMBL8350645 | 0.73 | MAPT (0.52) | MAPTTSHRLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL10731084 | 0.72 | HTR1A (0.71) | MAPTTSHRLMNAMAPK10MAPK1 | |
| SCHEMBL8351821 | 0.69 | MAPK10 (0.56) | MAPTTSHRLMNAMAPK10MAPK1 | |
| SCHEMBL8356499 | 0.69 | MAPK1 (0.61) | MAPTTSHRLMNAMAPK10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | claimed |
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |