Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HBB | P68871 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358213 | 0.87 | KDM4E (0.74) | LMNAPKML3MBTL1KDM4EALDH1A1 | |
| SCHEMBL8354273 | 0.78 | USP2 (0.69) | LMNAPKML3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL7356339 | 0.70 | ALDH1A1 (0.66) | PKMMAPK1KDM4EALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL1371732 | 0.69 | ALDH1A1 (0.64) | PKMKDM4EALDH1A1TSHRDRD2 | |
| SCHEMBL3488077 | 0.68 | ALDH1A1 (0.69) | PKMMAPK1KDM4EALDH1A1TSHR | |
| SCHEMBL5904228 | 0.68 | POLB (0.68) | LMNAPKML3MBTL1TSHRPOLB | |
| SCHEMBL8350034 | 0.68 | POLB (0.68) | LMNAPKML3MBTL1TSHRPOLB | |
| SCHEMBL12354954 | 0.68 | POLB (0.68) | LMNAPKML3MBTL1TSHRPOLB | |
| SCHEMBL27821654 | 0.68 | HTT (0.52) | LMNAPKML3MBTL1KDM4EALDH1A1 | |
| SCHEMBL8353613 | 0.68 | ALDH1A1 (0.74) | LMNAKDM4EALDH1A1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | claimed |
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |