SCHEMBL8350737

SCHEMBL8350737

O=C(COc1ccccc1)OCCCc1cc(C(c2ccccc2)c2ccccc2)no1

nearest known ligand 0.42

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 2/20 0.39
PTGDR Q13258 1/20 0.38
ALDH1A1 P00352 3/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
HDAC6 Q9UBN7 1/20 0.38
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
GAA P10253 1/20 0.37
NPC1 O15118 1/20 0.36
TSHR P16473 1/20 0.36
RAB9A P51151 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
EGFR P00533 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8356676 0.81 L3MBTL1 (0.40) PTGDR2ALDH1A1L3MBTL1MEN1KMT2A
SCHEMBL8355209 0.80 PTGDR2 (0.39) PTGDR2PTGDRALDH1A1L3MBTL1MEN1
SCHEMBL8965929 0.79 PTGDR2 (0.61) PTGDR2PTGDR
SCHEMBL8350655 0.78 ALDH1A1 (0.38) ALDH1A1L3MBTL1MEN1KMT2ANPC1
SCHEMBL8354926 0.78 ALDH1A1 (0.46) ALDH1A1L3MBTL1MEN1KMT2ANPC1
SCHEMBL8350734 0.76 PPARG (0.46) PTGDR2
SCHEMBL8356621 0.76 GPR84 (0.44) ALDH1A1MEN1KMT2AGAANPC1
SCHEMBL8354873 0.74 PTGDR2 (0.42) PTGDR2PTGDRALDH1A1MEN1KMT2A
SCHEMBL15931812 0.73 HDAC6 (0.52) ALDH1A1L3MBTL1HDAC6KMT2ANPC1
SCHEMBL8354897 0.72 ALDH1A1 (0.42) PTGDR2PTGDRALDH1A1L3MBTL1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5935985-A Phenoxyacetic acid derivatives ONO PHARMACEUTICAL CO., LTD. (JP) 1999-08-10 US disclosed
US-5703099-A TREATMENT OF THROMBOSIS, ARTERIOSCLEROSIS, ISCHEMIC HEART DISEASES, GASTRIC ULCER OR HYPERTENSION ONO PHARMACEUTICAL CO., LTD. (JP) 1997-12-30 US disclosed