Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 15/20 | 0.52 |
| ▸ | CTSK | P43235 | 9/20 | 0.49 |
| ▸ | CTSS | P25774 | 9/20 | 0.47 |
| ▸ | CTSB | P07858 | 8/20 | 0.47 |
| ▸ | GRN | P28799 | 1/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2155255 | 0.86 | CTSL (0.72) | CTSLCTSKCTSSCTSB | |
| SCHEMBL2155758 | 0.82 | GRN (0.64) | CTSLCTSKCTSSCTSBGRN | |
| SCHEMBL12327770 | 0.82 | CTSL (0.50) | CTSLCTSKCTSSCTSB | |
| SCHEMBL8293572 | 0.77 | CTSK (0.76) | CTSLCTSKCTSSCTSB | |
| SCHEMBL8294942 | 0.76 | CTSL (0.61) | CTSLCTSKCTSSCTSB | |
| SCHEMBL8294127 | 0.76 | CTSL (0.61) | CTSLCTSKCTSSCTSB | |
| SCHEMBL14672982 | 0.76 | CTSL (0.53) | CTSLCTSKCTSSCTSB | |
| SCHEMBL8293576 | 0.74 | CTSL (0.54) | CTSLCTSKCTSSCTSB | |
| SCHEMBL2155322 | 0.73 | GRN (0.41) | CTSLCTSKCTSSCTSBGRN | |
| SCHEMBL8236603 | 0.72 | CTSL (0.54) | CTSLCTSKCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482924-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-05-21 | — | — | EP | disclosed |
| WO-2003075836-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2003-09-18 | — | — | WO | disclosed |