Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 14/20 | 0.50 |
| ▸ | CTSK | P43235 | 12/20 | 0.49 |
| ▸ | CTSS | P25774 | 10/20 | 0.47 |
| ▸ | CTSB | P07858 | 9/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2157368 | 0.88 | CTSL (0.68) | CTSLCTSKCTSSCTSB | |
| SCHEMBL8352011 | 0.82 | CTSL (0.52) | CTSLCTSKCTSSCTSB | |
| SCHEMBL2155055 | 0.76 | CTSL (0.84) | CTSLCTSKCTSSCTSB | |
| SCHEMBL8293572 | 0.76 | CTSK (0.76) | CTSLCTSKCTSSCTSB | |
| SCHEMBL2155822 | 0.76 | CTSL (0.73) | CTSLCTSKCTSSCTSB | |
| SCHEMBL8294942 | 0.75 | CTSL (0.61) | CTSLCTSKCTSSCTSB | |
| SCHEMBL8294127 | 0.75 | CTSL (0.61) | CTSLCTSKCTSSCTSB | |
| SCHEMBL2156491 | 0.74 | CTSL (0.81) | CTSLCTSKCTSSCTSB | |
| SCHEMBL2156778 | 0.73 | CTSL (0.66) | CTSLCTSKCTSSCTSB | |
| SCHEMBL8288060 | 0.73 | CTSK (0.81) | CTSLCTSKCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130035312-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBIORS | AXYS PHARMACEUTICALS, INC. (US) | 2013-02-07 | — | — | US | disclosed |
| US-8318748-B2 | Cathepsin cysteine protease inhibitors | Merck, Sharp & Dohme Corp. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20110230446-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035312-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBIORS | CTSB, CTSS, CTSZ | CTSL 8/4885CTSK 4/4885CTSS 2/4885 |
| US-20110230446-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | CTSB, CTSS, CTSZ | CTSL 8/4885CTSK 4/4885CTSS 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.