Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8346739 | 0.74 | PGK1 (0.44) | PTGS1PTGS2KDM4EHPGDALDH1A1 | |
| SCHEMBL8351974 | 0.74 | PDCD1 (0.34) | PTGS1PTGS2KDM4EHPGDALDH1A1 | |
| SCHEMBL8346722 | 0.70 | KDM4E (0.33) | KDM4E | |
| SCHEMBL23571486 | 0.69 | PTGS1 (0.47) | PTGS1PTGS2KDM4EHPGDALDH1A1 | |
| SCHEMBL22777781 | 0.64 | DHODH (0.49) | PTGS1PTGS2KDM4EHPGDALDH1A1 | |
| SCHEMBL8346853 | 0.63 | KDM4E (0.31) | KDM4E | |
| SCHEMBL8347708 | 0.62 | VNN1 (0.32) | — | |
| SCHEMBL570407 | 0.61 | ALDH1A1 (0.61) | PTGS1PTGS2KDM4EHPGDALDH1A1 | |
| SCHEMBL8348909 | 0.59 | KDM4E (0.35) | PTGS1PTGS2KDM4EALDH1A1MAPT | |
| SCHEMBL8349224 | 0.59 | EED (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958904-A | Phosphonomethyl-imidazo 1,2-A! pyrimidine-2-carboxylic acid compounds for treatment of neurotoxic injury | G.D. SEARLE & CO. (US) | 1999-09-28 | — | — | US | disclosed |