Sugi Predict

Sugi Predict / Compounds / SCHEMBL835214

SCHEMBL835214

SCHEMBL835214

CCc1ccc([C@@H](O)[C@H](C)N)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 5/20 0.57
▸ LMNA P02545 3/20 0.57
▸ HIF1A Q16665 2/20 0.57
▸ ADRA2A P08913 1/20 0.57
▸ ADRA2C P18825 1/20 0.57
▸ ALDH1A1 P00352 1/20 0.55
▸ TDP1 Q9NUW8 5/20 0.50
▸ RECQL P46063 4/20 0.50
▸ MAPT P10636 3/20 0.50
▸ TSHR P16473 2/20 0.50
▸ ALOX15 P16050 1/20 0.50
▸ NFKB1 P19838 1/20 0.50
▸ THPO P40225 1/20 0.50
▸ HSD17B10 Q99714 1/20 0.50
▸ POLB P06746 1/20 0.50
▸ APEX1 P27695 1/20 0.50
▸ MTOR P42345 1/20 0.50
▸ BLM P54132 1/20 0.50
▸ KMT2A Q03164 1/20 0.50
▸ MAPK1 P28482 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18660812 1.00 KDM4E (0.57) KDM4ELMNAHIF1AADRA2AADRA2C
SCHEMBL14185860 1.00 KDM4E (0.57) KDM4ELMNAHIF1AADRA2AADRA2C
SCHEMBL3686505 0.84 TSHR (0.54) LMNAHIF1AALDH1A1TDP1TSHR
SCHEMBL28629132 0.83 TSHR (0.48) LMNAHIF1AALDH1A1TDP1TSHR
SCHEMBL6055175 0.83 TSHR (0.48) LMNAHIF1AALDH1A1TDP1TSHR
SCHEMBL835649 0.80 KDM4E (0.48) KDM4ELMNAHIF1AADRA2AADRA2C
SCHEMBL8284919 0.78 ADRB2 (0.52) LMNAALDH1A1TDP1TSHRMAPK1
SCHEMBL19466093 0.78 TSHR (0.52) LMNAALDH1A1TDP1TSHRMAPK1
SCHEMBL4800119 0.78 ADRB2 (0.52) LMNAALDH1A1TDP1TSHRMAPK1
SCHEMBL12808597 0.78 ADRB2 (0.52) LMNAALDH1A1TDP1TSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108368094-B Non-steroidal glucocorticoid receptor modulators for topical drug delivery 利奥制药有限公司 2021-07-02 — — CN disclosed
EP-3350175-B1 NON-STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS FOR LOCAL DRUG DELIVERY LEO PHARMA AS (DK) 2019-11-06 — — EP disclosed
EP-3350175-B1 NON-STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS FOR LOCAL DRUG DELIVERY LEO PHARMA AS (DK) 2019-11-06 — — EP disclosed
US-20180258080-A1 NON-STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS FOR LOCAL DRUG DELIVERY LEO PHARMA A/S (DK) 2018-09-13 — — US disclosed
WO-2017046096-A1 NON-STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS FOR LOCAL DRUG DELIVERY LEO PHARMA A/S (DK) 2017-03-23 — — WO disclosed
US-20120252770-A1 Chemical Compounds 572 BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-10-04 — — US disclosed
US-20120252770-A1 Chemical Compounds 572 BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-10-04 — — US disclosed
US-20120252770-A1 Chemical Compounds 572 BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-10-04 — — US disclosed
EP-2102169-B1 INDAZOLYL AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS ASTRAZENECA AB (SE) 2012-06-20 — — EP disclosed
US-8143290-B2 Chemical compounds 572 ASTRAZENECA AB (SE) 2012-03-27 — — US disclosed
US-20110071194-A1 Chemical Compounds 572 BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2011-03-24 — — US disclosed
US-20100197644-A1 Chemical Compounds 572 BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2010-08-05 — — US disclosed
US-20100197644-A1 Chemical Compounds 572 BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2010-08-05 — — US disclosed
US-20100197644-A1 Chemical Compounds 572 BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2010-08-05 — — US disclosed
US-7728030-B2 Chemical compounds 572 ASTRAZENECA AB (SE) 2010-06-01 — — US disclosed
US-7728030-B2 Chemical compounds 572 ASTRAZENECA AB (SE) 2010-06-01 — — US disclosed
US-7728030-B2 Chemical compounds 572 ASTRAZENECA AB (SE) 2010-06-01 — — US disclosed
US-20080214641-A1 Chemical compounds 572 BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2008-09-04 — — US disclosed
US-20080214641-A1 Chemical compounds 572 BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2008-09-04 — — US disclosed
US-20080214641-A1 Chemical compounds 572 BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2008-09-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080214641-A1 Chemical compounds 572 ABCG2, ABCB1, CYP11B2 KDM4E 2848/4885LMNA 1618/4885HIF1A 2420/4885
US-20100197644-A1 Chemical Compounds 572 ABCG2, ABCB1, CYP11B2 KDM4E 2848/4885LMNA 1618/4885HIF1A 2420/4885
US-20120252770-A1 Chemical Compounds 572 ABCG2, ABCB1, CYP11B2 KDM4E 2848/4885LMNA 1618/4885HIF1A 2420/4885
US-20180258080-A1 NON-STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS FOR LOCAL DRUG DELIVERY NR3C1, MC2R, NR3C2 KDM4E 4253/4885LMNA 2462/4885HIF1A 2610/4885
US-20110071194-A1 Chemical Compounds 572 ABCG2, ABCB1, CYP11B2 KDM4E 2848/4885LMNA 1618/4885HIF1A 2420/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.