Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | SGK1 | O00141 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | PRKX | P51817 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8359202 | 1.00 | PARP1 (0.48) | PARP1PTGESCHRM1SGK1PLK4 | |
| SCHEMBL8354196 | 0.83 | PARP1 (0.51) | PARP1CHRM1SGK1PRMT5SIGMAR1 | |
| SCHEMBL8357643 | 0.83 | PARP1 (0.51) | PARP1CHRM1SGK1PRMT5SIGMAR1 | |
| SCHEMBL14614929 | 0.82 | PTGES (0.59) | PTGESPLK4CHEK1AURKADAPK3 | |
| SCHEMBL8357104 | 0.77 | HRH3 (0.48) | PARP1ROCK1MEN1KMT2AHRH3 | |
| SCHEMBL8354510 | 0.77 | HRH3 (0.48) | PARP1ROCK1MEN1KMT2AHRH3 | |
| SCHEMBL8354199 | 0.77 | ROCK2 (0.56) | PARP1ROCK1HRH3 | |
| SCHEMBL8358764 | 0.77 | ROCK2 (0.56) | PARP1ROCK1HRH3 | |
| SCHEMBL28917070 | 0.76 | CDK2 (0.56) | PARP1PTGESPLK4CHEK1AURKA | |
| Hydrochloric Acid SCHEMBL4885642 | 0.76 | PLK4 (0.50) | PLK4CHEK1AURKADAPK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305675-A1 | Indazoles, Benzothiazoles, and Benzoisothiazoles, and preparation and uses thereof | Memory Pharmaceuticals Corporation (US) | 2011-04-06 | — | — | EP | disclosed |
| WO-2004029050-A1 | INDAZOLES, BENZOTHIAZOLES, AND BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-04-08 | — | — | WO | disclosed |