Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.51 |
| ▸ | TNKS | O95271 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.44 |
| ▸ | SGK1 | O00141 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8354196 | 1.00 | PARP1 (0.51) | PARP1TNKSCHRM1SIGMAR1SGK1 | |
| SCHEMBL8359202 | 0.83 | PARP1 (0.48) | PARP1CHRM1SIGMAR1SGK1PRMT5 | |
| SCHEMBL8354859 | 0.83 | PARP1 (0.48) | PARP1CHRM1SIGMAR1SGK1PRMT5 | |
| SCHEMBL14748055 | 0.79 | NPC1 (0.69) | PARP1SIGMAR1CNR2CNR1 | |
| SCHEMBL8357618 | 0.79 | NPC1 (0.69) | PARP1SIGMAR1CNR2CNR1 | |
| SCHEMBL8357104 | 0.77 | HRH3 (0.48) | PARP1 | |
| SCHEMBL8358764 | 0.77 | ROCK2 (0.56) | PARP1 | |
| SCHEMBL8354199 | 0.77 | ROCK2 (0.56) | PARP1 | |
| SCHEMBL8354510 | 0.77 | HRH3 (0.48) | PARP1 | |
| SCHEMBL11609236 | 0.74 | SIGMAR1 (0.60) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543000-B1 | INDAZOLES, BENZOTHIAZOLES, AND BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2013-03-06 | — | — | EP | disclosed |
| EP-2305675-A1 | Indazoles, Benzothiazoles, and Benzoisothiazoles, and preparation and uses thereof | Memory Pharmaceuticals Corporation (US) | 2011-04-06 | — | — | EP | disclosed |
| WO-2004029050-A1 | INDAZOLES, BENZOTHIAZOLES, AND BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-04-08 | — | — | WO | disclosed |